May 31, 2025
Story at-a-glance
- Long-term antidepressant use significantly increases the risk of sudden cardiac death, with risk doubling after six or more years of use according to Danish research
- Younger adults face an even higher risk, with those aged 30 to 39 showing five times greater likelihood of sudden cardiac death after six years on antidepressants
- Antidepressants disrupt heart rhythm by affecting ion channels, triggering fatal irregular heartbeat
- Research shows antidepressants only benefit about 15% of patients beyond placebo effect, primarily those with severe depression rather than general low mood
- Effective alternatives for managing depression include exercise, sunlight exposure, gut health optimization and techniques for nervous system regulation